abstract：:Cardiotrophin-1 (CT-1) is a heart-targeting cytokine that is increased in the metabolic syndrome due to overexpression in the adipocytes. The effects of CT-1 on cardiomyocyte substrate metabolism remain unknown. We therefore determined the effects of CT-1 on basal and stimulated glucose transport in cardiomyocytes exp...

journal_title：Journal of molecular and cellular cardiology

authors： Asrih M,Gardier S,Papageorgiou I,Montessuit C

更新日期：2013-03-01 00:00:00

abstract：:Efficacy of intravenous administration of mesenchymal stromal cells (MSCs) for myocardial infarction (MI) is limited by low cell retention in the damaged myocardium. Previous studies indicated that remote ischemic conditioning could protect against ischemia-reperfusion-induced injury by release of various cytokines in...

journal_title：Journal of molecular and cellular cardiology

authors： Jiang Q,Song P,Wang E,Li J,Hu S,Zhang H

更新日期：2013-03-01 00:00:00

abstract：:During lipid oversupply, the heart becomes insulin resistant, as exemplified by defective insulin-stimulated glucose uptake, and will develop diastolic dysfunction. In the healthy heart, not only insulin, but also increased contractile activity stimulates glucose uptake. Upon increased contraction both AMP-activated p...

journal_title：Journal of molecular and cellular cardiology

authors： Steinbusch LK,Dirkx E,Hoebers NT,Roelants V,Foretz M,Viollet B,Diamant M,van Eys G,Ouwens DM,Bertrand L,Glatz JF,Luiken JJ

更新日期：2013-02-01 00:00:00

abstract：:The processes of excitation-contraction coupling in cardiac myocytes require enormous amounts of energy in the form of ATP, which is produced by oxidative phosphorylation in mitochondria. Due to the constantly varying workloads of the heart, efficient matching of energy supply to demand is a requisite for proper heart...

journal_title：Journal of molecular and cellular cardiology

authors： Dorn GW 2nd,Maack C

更新日期：2013-02-01 00:00:00

abstract：:The electrophysiological heterogeneity that exists across the ventricular wall in the mammalian heart has long been recognized, but remains an area that is incompletely understood. Experimental studies of the mechanisms of arrhythmogenesis in the whole heart often examine the epicardial surface in isolation and thereb...

journal_title：Journal of molecular and cellular cardiology

authors： Di Diego JM,Sicouri S,Myles RC,Burton FL,Smith GL,Antzelevitch C

更新日期：2013-01-01 00:00:00

abstract：:Autophagy is a process that removes damaged proteins and organelles and is of particular importance in terminally differentiated cells such as cardiomyocytes, where it has primarily a protective role. We investigated the involvement of inositol(1,4,5)trisphosphate (Ins(1,4,5)P(3)) and its receptors in autophagic respo...

journal_title：Journal of molecular and cellular cardiology

authors： Wong A,Grubb DR,Cooley N,Luo J,Woodcock EA

更新日期：2013-01-01 00:00:00

abstract：:We measured myosin crossbridge detachment rate and the rates of MgADP release and MgATP binding in mouse and rat myocardial strips bearing one of the two cardiac myosin heavy chain (MyHC) isoforms. Mice and rats were fed an iodine-deficient, propylthiouracil diet resulting in ~100% expression of β-MyHC in the ventricl...

journal_title：Journal of molecular and cellular cardiology

authors： Wang Y,Tanner BC,Lombardo AT,Tremble SM,Maughan DW,Vanburen P,Lewinter MM,Robbins J,Palmer BM

更新日期：2013-01-01 00:00:00

abstract：:Rapamycin (Sirolimus®) is used to prevent rejection of transplanted organs and coronary restenosis. We reported that rapamycin induced cardioprotection against ischemia-reperfusion (I/R) injury through opening of mitochondrial K(ATP) channels. However, signaling mechanisms in rapamycin-induced cardioprotection are cur...

journal_title：Journal of molecular and cellular cardiology

authors： Das A,Salloum FN,Durrant D,Ockaili R,Kukreja RC

更新日期：2012-12-01 00:00:00

abstract：:The E2F4-p130 transcriptional repressor complex is a cell-cycle inhibitor in mitotic cells. However, the role of E2F4/p130 in differentiated cells is largely unknown. We investigated the role of E2F4/p130 in the regulation of apoptosis in postmitotic cardiomyocytes. Here we demonstrate that E2F4 can inhibit hypoxia-in...

journal_title：Journal of molecular and cellular cardiology

authors： Dingar D,Konecny F,Zou J,Sun X,von Harsdorf R

更新日期：2012-12-01 00:00:00

abstract：:Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K(+) channel that contributes to the repolarization of the cardiac action potential. We have previously shown that hERG mRNA transcripts that contain premature termination codon mutations are rapi...

journal_title：Journal of molecular and cellular cardiology

authors： Stump MR,Gong Q,Packer JD,Zhou Z

更新日期：2012-11-01 00:00:00

abstract：:Common cardiovascular diseases such as hypertension and myocardial infarction require that myocytes develop greater than normal force to maintain cardiac pump function. This requires increases in [Ca(2+)]. These diseases induce cardiac hypertrophy and increases in [Ca(2+)] are known to be an essential proximal signal ...

journal_title：Journal of molecular and cellular cardiology

authors： Gao H,Wang F,Wang W,Makarewich CA,Zhang H,Kubo H,Berretta RM,Barr LA,Molkentin JD,Houser SR

更新日期：2012-11-01 00:00:00

abstract：:The currently used biomarkers for acute myocardial infarction (AMI) are blood creatinine phosphokinase-muscle band (CPK-MB), troponin-T (TnT), and troponin I (TnI). However, no good biomarkers are identified in urine after AMI, because these blood protein biomarkers are difficult to be filtered into urine. In this stu...

journal_title：Journal of molecular and cellular cardiology

authors： Cheng Y,Wang X,Yang J,Duan X,Yao Y,Shi X,Chen Z,Fan Z,Liu X,Qin S,Tang X,Zhang C

更新日期：2012-11-01 00:00:00

abstract：:Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K(+) channel ancillary subunit gene. New-onset postoperative AF (POAF) generally occurs 48-72 h after major surgery, particularly following procedures within t...

journal_title：Journal of molecular and cellular cardiology

authors： Heerdt PM,Kant R,Hu Z,Kanda VA,Christini DJ,Malhotra JK,Abbott GW

更新日期：2012-09-01 00:00:00

abstract：:Increasing heart rate enhances cardiac contractility (force frequency relationship, FFR) and accelerates cardiac relaxation (frequency-dependent acceleration of relaxation, FDAR). The positive FFR together with FDAR promotes rapid filling and ejection of blood from the left ventricle (LV) at higher heart rates. Recent...

journal_title：Journal of molecular and cellular cardiology

authors： Wu Y,Luczak ED,Lee EJ,Hidalgo C,Yang J,Gao Z,Li J,Wehrens XH,Granzier H,Anderson ME

更新日期：2012-09-01 00:00:00

abstract：:Pacemaker (HCN) channels have a key role in the generation and modulation of spontaneous activity of sinoatrial node myocytes. Previous work has shown that compartmentation of HCN4 pacemaker channels within caveolae regulates important functions, but the molecular mechanism responsible is still unknown. HCN channels h...

journal_title：Journal of molecular and cellular cardiology

authors： Barbuti A,Scavone A,Mazzocchi N,Terragni B,Baruscotti M,Difrancesco D

更新日期：2012-08-01 00:00:00

abstract：:Syndecan-4 (synd4) is a heparan sulfate proteoglycan, involved in repair following tissue damage, through modulating neovascularization and inflammation. In acute myocardial infarction its myocardial expression is up-regulated in a time-dependent manner, and in synd4-deficient mice severe cardiac dysfunction and abnor...

journal_title：Journal of molecular and cellular cardiology

authors： Xie J,Wang J,Li R,Dai Q,Yong Y,Zong B,Xu Y,Li E,Ferro A,Xu B

更新日期：2012-08-01 00:00:00

abstract：:We evaluated the hypothesis that uterine cells home to the heart after injury and improve cardiac outcomes. Premenopausal women have fewer cardiovascular complications than age-matched men, but the mechanisms responsible for this protection have not been conclusively identified. Hysterectomy was performed in young fem...

journal_title：Journal of molecular and cellular cardiology

authors： Xaymardan M,Sun Z,Hatta K,Tsukashita M,Konecny F,Weisel RD,Li RK

更新日期：2012-06-01 00:00:00

abstract：:Attenuation of excessive rates of myocardial glycolysis limits proton production and Ca(2+) overload during reperfusion and improves recovery of post-ischemic left ventricular (LV) function. In order to elucidate mechanisms underlying glycolytic inhibition by adenosine (ADO), this study tested the hypothesis that the ...

journal_title：Journal of molecular and cellular cardiology

authors： Omar MA,Verma S,Clanachan AS

更新日期：2012-06-01 00:00:00

abstract：:Atrial fibrillation, the most common sustained arrhythmia, is believed to be triggered by ectopic electrical activity originating in the myocardial sleeves surrounding the pulmonary veins (PVs). It has been reported that myocardial sleeves have the potential to generate automaticity in response to norepinephrine. This...

journal_title：Journal of molecular and cellular cardiology

authors： Okamoto Y,Takano M,Ohba T,Ono K

更新日期：2012-05-01 00:00:00

abstract：:Although endothelial progenitor cells (EPCs) play a pivotal role in the endothelial repair following arterial injury and shear stress has a beneficial effect on EPCs, however, the molecular mechanism underlying the influence of EPCs on the endothelial integrity and the regulation of shear stress on the EPC signaling r...

journal_title：Journal of molecular and cellular cardiology

authors： Yang Z,Xia WH,Zhang YY,Xu SY,Liu X,Zhang XY,Yu BB,Qiu YX,Tao J

更新日期：2012-05-01 00:00:00

abstract：:The coronary collateral circulation is critically important as an adaptation of the heart to prevent the damage from ischemic insults. In their native state, collaterals in the heart would be classified as part of the microcirculation, existing as arterial-arterial anastomotic connections in the range of 30 to 100 μM ...

journal_title：Journal of molecular and cellular cardiology

authors： Chilian WM,Penn MS,Pung YF,Dong F,Mayorga M,Ohanyan V,Logan S,Yin L

更新日期：2012-04-01 00:00:00

abstract：:Coronary blood flow is tightly adjusted to the oxygen requirements of the myocardium. The underlying control mechanisms keep coronary venous pO(2) at a rather constant level around 20mm Hg under a variety of physiological conditions. Because coronary flow may increase more than 5-fold during exercise without any signs...

journal_title：Journal of molecular and cellular cardiology

authors： Deussen A,Ohanyan V,Jannasch A,Yin L,Chilian W

更新日期：2012-04-01 00:00:00

abstract：:The post-translational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAc) is emerging as an important mechanism for the regulation of numerous biological processes critical for normal cell function. Active...

journal_title：Journal of molecular and cellular cardiology

authors： Darley-Usmar VM,Ball LE,Chatham JC

更新日期：2012-03-01 00:00:00

abstract：:AT1 receptor blockers (ARB) and in part ACE inhibitors (ACI) potentially exert beneficial effects on atherogenesis independent of AT1 receptor inhibition. These pleiotropic effects might be related to angiotensin II mediated activation of the AT2 receptor. To analyze this hypothesis we investigated the development of ...

journal_title：Journal of molecular and cellular cardiology

authors： Tiyerili V,Mueller CF,Becher UM,Czech T,van Eickels M,Daiber A,Nickenig G,Wassmann S

更新日期：2012-03-01 00:00:00

abstract：:Mitochondria are highly metabolically active cell organelles that not only act as the powerhouse of the cell by supplying energy through ATP production, but also play a destructive role by initiating cell death pathways. Growing evidence recognizes that mitochondrial dysfunction is one of the major causes of cardiovas...

journal_title：Journal of molecular and cellular cardiology

authors： Das S,Steenbergen C

更新日期：2012-02-01 00:00:00

abstract：:Cardiac myosin binding protein-C (cMyBP-C) has 11 immunoglobulin or fibronectin-like domains, C0 through C10, which bind sarcomeric proteins, including titin, myosin and actin. Using bacterial expressed mouse N-terminal fragments (C0 through C3) in an in vitro motility assay of myosin-generated actin movement and the ...

journal_title：Journal of molecular and cellular cardiology

authors： Weith A,Sadayappan S,Gulick J,Previs MJ,Vanburen P,Robbins J,Warshaw DM

更新日期：2012-01-01 00:00:00

abstract：:Myocardial infarction (MI) is one of the leading causes of morbidity and mortality world-wide. Whether endogenous repair and regenerative ability could be augmented by drug administration is an important issue for generation of novel therapeutic approach. Recently it was reported that in mice pretreated with thymosin ...

journal_title：Journal of molecular and cellular cardiology

authors： Zhou B,Honor LB,Ma Q,Oh JH,Lin RZ,Melero-Martin JM,von Gise A,Zhou P,Hu T,He L,Wu KH,Zhang H,Zhang Y,Pu WT

更新日期：2012-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that control expression of complementary target mRNAs. A growing number of miRNAs has been implicated in the pathogenesis of cardiac diseases, mostly based not on functional data, but on the observation that they are dysregulated in diseased myocardium. Consequently, our kn...

journal_title：Journal of molecular and cellular cardiology

authors： Jentzsch C,Leierseder S,Loyer X,Flohrschütz I,Sassi Y,Hartmann D,Thum T,Laggerbauer B,Engelhardt S

更新日期：2012-01-01 00:00:00

abstract：:E2Fs are a family of transcription factors that regulate proliferation, differentiation and apoptosis in many cell types. E2F-1 is the prototypical E2F and the family member that has most often been implicated in also mediating apoptosis. To better understand the role of E2F-1 in mediating cardiomyocyte injury we init...

journal_title：Journal of molecular and cellular cardiology

authors： Angelis E,Zhao P,Zhang R,Goldhaber JI,Maclellan WR

更新日期：2011-12-01 00:00:00

abstract：:To explore whether CaMKII-dependent phosphorylation events mediate reperfusion arrhythmias, Langendorff perfused hearts were submitted to global ischemia/reperfusion. Epicardial monophasic or transmembrane action potentials and contractility were recorded. In rat hearts, reperfusion significantly increased the number ...

journal_title：Journal of molecular and cellular cardiology

authors： Said M,Becerra R,Valverde CA,Kaetzel MA,Dedman JR,Mundiña-Weilenmann C,Wehrens XH,Vittone L,Mattiazzi A

更新日期：2011-12-01 00:00:00

abstract：:Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative condition with a heterogeneous cardiac phenotype caused primarily by an expanded GAA trinucleotide repeat in the frataxin gene (FXN). FXN is important in mitochondrial iron efflux, sensitivity to oxidative stress, and cell death. The number of GAA re...

journal_title：Journal of molecular and cellular cardiology

authors： Kelly M,Bagnall RD,Peverill RE,Donelan L,Corben L,Delatycki MB,Semsarian C

更新日期：2011-11-01 00:00:00

abstract：:Tetrahydrobiopterin (BH(4)) is an essential cofactor for aromatic amino acid hydroxylases and for all three nitric oxide synthase (NOS) isoforms. It also has a protective role in the cell as an antioxidant and scavenger of reactive nitrogen and oxygen species. Experimental studies in humans and animals demonstrate tha...

journal_title：Journal of molecular and cellular cardiology

authors： Moens AL,Kietadisorn R,Lin JY,Kass D

更新日期：2011-10-01 00:00:00

abstract：:Calorie restriction is considered to be the best environmental intervention providing health benefits to mammals. The underlying mechanism of this intervention seems to be controlled by a group of NAD-dependent deacetylases, collectively called sirtuins. In mammals, there are seven sirtuin analogs, SIRT1-SIRT7. The fo...

journal_title：Journal of molecular and cellular cardiology

authors： Sundaresan NR,Pillai VB,Gupta MP

更新日期：2011-10-01 00:00:00

abstract：:Fibroblasts play a pivotal role in cardiac remodeling and the development of heart failure through the deposition of extra-cellular matrix (ECM) proteins and also by affecting cardiomyocyte growth and function. The renin-angiotensin system (RAS) is a key regulator of the cardiovascular system in health and disease and...

journal_title：Journal of molecular and cellular cardiology

authors： Iwata M,Cowling RT,Yeo SJ,Greenberg B

更新日期：2011-10-01 00:00:00

abstract：:Thyroid hormone has unique properties affecting the heart, and the vasculature and cholesterol metabolism. There is interest in using thyromimetic agents as possible treatment options for heart failure based on data demonstrating the ability of these agents to improve systolic and diastolic left ventricular function a...

journal_title：Journal of molecular and cellular cardiology

authors： Arsanjani R,McCarren M,Bahl JJ,Goldman S

更新日期：2011-10-01 00:00:00

abstract：:Acquired cardiovascular diseases such as coronary heart disease, peripheral artery disease and related vascular problems contribute to more than one-third of worldwide morbidity and mortality. In many instances, particularly in the under developed world, cardiovascular diseases are diagnosed at a late stage limiting t...

journal_title：Journal of molecular and cellular cardiology

authors： Emeto TI,Moxon JV,Rush C,Woodward L,Golledge J

更新日期：2011-09-01 00:00:00

abstract：:Viscosity is proposed to modulate diastolic function, but only limited understanding of the source(s) of viscosity exists. In vitro experiments have shown that the proline-glutamic acid-valine-lysine (PEVK) rich element of titin interacts with actin, causing a viscous force in the sarcomere. It is unknown whether this...

journal_title：Journal of molecular and cellular cardiology

authors： Chung CS,Methawasin M,Nelson OL,Radke MH,Hidalgo CG,Gotthardt M,Granzier HL

更新日期：2011-09-01 00:00:00

abstract：:Preconditioning of hearts with the α(1)-adrenoceptor agonist phenylephrine decreases infarct size and increases the functional recovery of the heart following ischaemia-reperfusion. However, the cellular mechanisms responsible for this protection are not known. We investigated the role of protein kinase C ε and δ (PKC...

journal_title：Journal of molecular and cellular cardiology

authors： Turrell HE,Rodrigo GC,Norman RI,Dickens M,Standen NB

更新日期：2011-09-01 00:00:00

abstract：:Recently it was shown that lipopolysaccharide (LPS) impairs the pacemaker current in human atrial myocytes. It was speculated that reduced heart rate variability (HRV), typical of patients with severe sepsis, may partially be explained by this impairment. We evaluated the effect of various types of LPS on the activity...

journal_title：Journal of molecular and cellular cardiology

authors： Klöckner U,Rueckschloss U,Grossmann C,Ebelt H,Müller-Werdan U,Loppnow H,Werdan K,Gekle M

更新日期：2011-08-01 00:00:00

abstract：:We have previously reported that resistin induces hypertrophy and impairs contractility in isolated rat cardiomyocytes. To examine the long-term cardiovascular effects of resistin, we induced in vivo overexpression of resistin using adeno-associated virus serotype 9 injected by tail vein in rats and compared to contro...

journal_title：Journal of molecular and cellular cardiology

authors： Chemaly ER,Hadri L,Zhang S,Kim M,Kohlbrenner E,Sheng J,Liang L,Chen J,K-Raman P,Hajjar RJ,Lebeche D

更新日期：2011-08-01 00:00:00